Endocrine Abstracts

Wolfram syndrome is a rare, autosomal recessive entity characterized by several progressive neurodegenerative manifestations.Observation: We report the case of a 27-year-old patient from a Consanguineous marriage, followed for hypogonadism with delayed puberty and insulin-requiring diabetes since the age of 13 with negative autoantibodies. His diabetes is complicated after 5 years of a mainly vegetative neuropathy with neurogenic bladder complicated by b...

Introduction: Several studies have incriminated hypomagnesemia in the pathophysiology of diabetes, as the prevalence of this deficit in type 2 diabetics is high, and as it is correlated with glycemic control and chronic diabetic complications.Aims: Studying the prevalence of hypomagnesemia in type 2 diabetics and assessing its impact on quality of life, glycemic control and chronic diabetic complications. Patients and methods: We conducted a descriptive ...

Introduction: Verneuil’s disease, also known as Hidradenitis suppurativa, is a chronic inflammatory dermatosis characterized by recurrent episodes. It’s manifested by painful deep inflammatory nodules, comedones, and scarring in areas rich in apocrine glands. Its prevalence is estimated at 1% of the population. It is influenced by factors such as obesity, smoking, and genetics. We report the case of a patient admitted for diabetes in whom Hidradenitis suppurativa was...

Introduction: Growth hormone deficiency (GHD) is a rare cause of growth retardation whose diagnosis remains relatively late. Its etiologies are multiple, and its treatment could improve the stature prognosis of the children. The objective of this study was to describe the clinical, biological, radiological, and therapeutic characteristics of GHD, and its outcomes after treatment.Methods: A cross-sectional study was conducted in the Endocrinology departme...

Introduction: The most recent declared pandemic is attributed to COVID-19, caused by the novel coronavirus SARS-CoV-2. The angiotensin-converting enzyme 2, the principal receptor for SARS-CoV-2, exhibits expression in various tissues, prominently within gonadal and hypothalamo-hypophyseal domains. Long COVID, characterized by persistent symptoms post-infection, manifests in certain individuals and includes manifestations associated with the genitourinary system, such as sexual...

Introduction : Few studies have considered the natural history of pituitary anatomy in Sheehan syndrome (SS), as seen on magnetic resonance imaging (MRI) or CT scan. An imaging study of the sella turcica was carried out in patients with SS. The aim was to look for correlations between radiological findings and the degree of endocrine insufficiency on the one hand, and diagnosis delay on the other.Methods: This is a retrospective study carried out between...

Introduction: Sheehan’s syndrome (SS) results from severe post-partum hemorrhage leading to necrosis of the pituitary gland. Here we describe the clinical characteristics of patients with Sheehan syndrome.Methods: We conducted a 44-year cohort study (1977 to 2021) of patients with SS followed at the endocrinology department of Farhat Hached Hospital in Sousse, Tunisia. Medical history, physical examination findings and laboratory investigations were...

Introduction: Macroprolactinemia is a polymeric form of prolactin release that leads to clinically paucisymptomatic presentations. It can be isolated or associated with other causes of hyperprolactinemia. We report the case of macroprolactinemia discovered in a patient being treated for an empty sella turcica.Case report: This concerns a 47-year-old patient, monitored since the age of 31 for moderate idiopathic hyperprolactinemia discovered following bil...

Introduction: Hamartomas are benign tumors that occur in many different parts of the body. Brain locations of hamartoma are rare but still reported in few cases such as the tuber cinereum (TC) location. Children with hypothalamic hamartomas develop precocious puberty generally associated with gelastic seizures. However, TC hamartomas do not necessarily induce clinical symptoms. Amenorrhea has never been reported as a revealing symptom of TC hamartomas. Here we describe an atyp...

Introduction: Pituitary adenomas stand as the most prevalent form of tumorous pathology impacting the pituitary gland in adults. Their discovery might arise from either hypersecretion in functional adenomas or the manifestation of compression symptoms on neighboring structures. Detection of a pituitary adenoma can occur incidentally during various imaging modalities, encompassing both structural and functional assessments. This study documents a case involving the incidental d...